The term "ovarian rejuvenation" has gained significant visibility on social media, fertility forums, and non-specialized media. In many of these spaces, it is presented as a solution to restore high-quality eggs and, consequently, improve the chances of pregnancy. However, the popularity of the concept is not always accompanied by scientific rigor. At Barcelona IVF, we aim to approach this new field of research with clarity, transparency, and a strong ethical commitment to our patients.
What is ovarian rejuvenation, really?
Under this term, various experimental strategies are grouped, aiming to stimulate the ovary to improve its function, either by increasing the number of available follicles or by encouraging the activation of "sleeping" follicles. Among the most prominent approaches are the use of platelet-rich plasma (PRP) and in vitro follicle activation (IVA). However, despite the interest they generate, none of these techniques have yet demonstrated sufficient efficacy to be considered a recommendable clinical treatment. The evidence available currently comes from very preliminary studies with results varying a lot, which makes them difficult to reproduce.
Common Myths About Ovarian Rejuvenation
Fertility is a sensitive topic, especially from an emotional standpoint. Uncertainty, the passage of time, and social pressure lead many women to actively seek potential solutions to improve their path to motherhood. In this context, it is crucial that patients receive honest, differentiated, and data-supported information.
- “PRP can increase ovarian reserve”
At times, PRP is attributed with the ability to "rejuvenate" the ovary or increase the number of available follicles. As of today, scientific evidence does not confirm that PRP can alter the ovarian reserve. What we do know is that this is a promising area of research, but still in its very early stages, so it is important to approach it with caution and always under the guidance of specialized medical advice. - “Women can recover young eggs”
At times, these techniques are interpreted as having the ability to "rejuvenate" the egg or reverse its biological age. However, current evidence indicates that neither PRP nor follicle activation strategies can alter the cellular age of oocytes. Oocyte quality continues to primarily depend on the woman's age, a factor that remains key in reproductive prognosis. - “Studies already show that it works”
Although there are publications exploring these techniques, most refer to very small studies or methodologies that do not yet allow for reliable comparisons. This means that, for now, we cannot draw solid conclusions about their efficacy or safety. Research is advancing, but larger and more controlled trials are needed before these techniques can be considered as established clinical options. - “It’s a reliable alternative to egg donation”
Currently, ovarian rejuvenation techniques cannot be considered a consolidated alternative to egg donation in cases of severe low ovarian reserve or advanced reproductive age. Egg donation remains the option with the best success rates when a woman's own oocytes do not offer realistic chances.
Commitment to Ethical and Responsible Communication
At Barcelona IVF , we strongly believe that the most valuable information is always grounded in scientific precision and personalized medical advice. For this reason, before considering any experimental technique it is essential to analyze each case individually, evaluate the possibilities based on solid evidence and understand where the real opportunities for success lie. We commit to supporting each patient with clarity, honesty and empathy. This way it can be ensured that our patients' decisions are based on reliable knowledge and safe, realistic medical advice.
Dr. Cristina Guix
Fertility Specialist at Barcelona IVF
